LifeGlimmer GmbH is an international Berlin-based science-driven company that caters advanced solutions for the full research pipeline in bioinformatics, data integration, and systems biology. From designing workflows, via sophisticated analytics and dynamic simulations, to new knowledge discovery and novel inroads to applications in both fundamental and applied biological and biomedical practice. LifeGlimmer GmbH offers tailored scientific solutions to deal with complexity in the biosciences.
We seek to advance your scientific projects with our services and consulting in experimental design and training activities in modelling, text mining, R and others.
Necrotizing soft tissue infection (NSTI) is an aggressively progressing bacterial infection. It usually starts from a small wound where bacteria invade the skin, but can subsequently lead to severe consequences including limb amputation or even death. It is crucial to start disease treatment as soon as first symptoms appear. However, it is not trivial to immediately diagnose the disease due to clinical heterogeneity, like the presence of comorbidities, a wide variety of different bacteria present, or occurrences of other similar symptoms like tenderness, swelling, or pain. To make identification of the disease easier and to anticipate disease progression and treatment, the INFECT consortium takes on a novel systems biology approach. The project will integrate clinical data with the underlying molecular data in order to understand the complex molecular mechanisms on the interface of human skin and invaded bacteria.
LifeGlimmer is a computational partner of the consortium. We integrate and visualise signalling interactions with experimental omics data to pinpoint disease-specific pathways and modules, and we develop causative models to try and reveal novel clinical signatures and to understand the interactions at the level of genetics and signalling. Moreover, LifeGlimmer aims to associate the clinical data with the molecular mechanisms. Since the INFECT project involves broad patient cohorts, we use advanced statistical methods to reveal associations between clinical parameters (like for example comorbidities, age, or BMI) and types of infection. Furthermore, LifeGlimmer uses advanced clustering methods to identify patient subgroups from heterogeneous clinical parameters with the aim of developing effective classification methods to predict disease progression.
SysmedIBD stands for Systems medicine of chronic Inflammatory Bowel Disease. The project started in December 2012 and is funded with 12 Mio Euro by the European Commission under the 7th Framework Programme. SysmedIBD brings together specialists from Europe, Israel and New Zealand and is centrally coordinated by Prof. Werner Müller at Manchester University. The main objective of SysmedIBD is to better understand chronic Inflammatory Bowel Disease and to find new approaches for therapies.
Microalgae are a promising new renewable feedstock for chemicals and plastics. They can be cultivated on non-arable land and can yield valuable compounds for chemical industries. If microcalgae can be sustainably utilized on an industrial scale this will provide new opportunities for decreased dependency on fossil feedstocks and potentially contribute to climate mitigation and reduced pressure on land resources.
The Marie Curie Initial Training Network PERFUME (PERoxisome Formation, Function, Metabolism) is an interdisciplinary and intersectoral initial stage training network (ITN) at the interface of medicine, plant and fungal biology, devoted to understanding the principles of peroxisome biology.
EmPowerPutida aims at developing the ultimate bacterial platform for whole-cell biocatalysis that is bound to take European chemical biotechnology into an unprecedented level of productivity and competitiveness. As a tightly intertwined and multidisciplinary team of 9 academic and industrial partners, the EmPowerPutida consortium aims to fill major technical and scientific gaps that, to this day, have limited the full-fledged application of contemporary Synthetic Biology to large-scale industrial biotechnology in Europe. It will do so by developing innovative workflows for the tailored engineering of the lifestyles of Pseudomonas putida, a bacterium with remarkable metabolic endowment and stress tolerant capabilities that make it superior to potential competitors. The ultimate goal of the project is thus to provide a robust platform for the generation of versatile, high performance Pseudomonas putida chassis directed at the sustainable biotechnological production of bulk and specialty chemicals. We have the ambition to set Pseudomonas putida as a major European platform of choice for industrial, large-scale whole-cell biocatalysis.
The cell nucleus is organized and compartmentalized into a highly ordered assembly that contains DNA, RNA, chromosomal and histone proteins that make up a structure called chromatin. The dynamics associated with these various components are responsible for regulating physiological processes and the overall stability of the genome. The destabilization of such regulatory mechanisms that act on the chromatin structure are implicated in pathologies, such as cancer. Higher order organization of chromatin results in chromosomes that occupy discrete territories within the cell nucleus. Most nuclear processes occur or at least being initiated onto the chromosomes which makes them the main organizing factors in the nucleus. Several proteins that are involved in the replication of DNA, gene transcription and the processing of RNA are found enriched in discrete focal structures. An emerging theme is how these structures assemble and are maintained in the absence of membranes and moreover what are the kinetics of stable binding and/or rapid exchange of their components. The dynamic assembly and modification of chromatin during developmental processes as well as the deregulation of such chromatin dynamics during the onset of disease lacks mechanistic insights at present. To address these questions we have put forward a multidisciplinary approach which involves molecular, cellular and systems level approaches by assembling a group of scientists from both academic and non-academic partners with cross disciplinary expertise and capabilities.
The aim of NORM-SYS is to incorporate established community standards for data and in silico models in systems biology into generalized concepts that enable easy communication between expert groups and standardization organisations.